What many consumers don’t realise is that the vast majority of supplements available do not have any clinical testing performed on the actual products being sold.  

This is because it is not a legal requirement and as such many companies supplying these supplements simply do not bother. 

Human trials on other NAD supplementation options like NMN and NR are extremely rare. 

However, this is definitely not the case for Nuchido’s Time+ NAD booster.  

Nuchido is one of the only supplement brands to conduct such a trial on their product, setting them apart from the rest of the competition. Making Nuchido a true pioneer in the field. 

Nuchido’s Time+ is a dietary supplement and second-generation NAD+ booster designed to increase the levels of Cellular NAD+.  

It has been developed by a team of highly specialised Scientists, Molecular Biologists, and Systems Pharmacologists. 

Time+ is a superior NAD booster to traditional precursor-only supplements like NMN and NR because it has a different and more effective “Mechanism of Action”.  

It not only significantly increases NAD+ levels in the cells but it also restores the body's natural NAD+ production process. The Salvage Pathway. 

This groundbreaking dietary supplement that has been put to the test through a rigorous clinical trial, and the results are nothing short of remarkable. 
 
How does feeling and looking over a year younger in less than a month! Time+ has the power to reduce your biological age by an average of 1.26 years after just 28 days of supplementation.  

So, what about the clinical trial? Was it an authentic trial or just an in-house review of some random data.   

The legitimacy of the trial and results can be obtained by addressing the following questions; 

• What was the nature of the clinical trial? Was it designed to meet rigorous scientific standards? 
• Were the results of the trial comparable to other trials in the field of NAD supplementation? 
• Was the trial conducted by reputable scientists and researchers in the field? 
• Did the trial assess multiple outcomes related to NAD+ and aging? 

By addressing these questions, we can gain a better understanding of the clinical trial's credibility, validity, and how it compares to other trials in the field. 

What was the nature of the clinical trial? Was it designed to meet rigorous scientific standards? 

• The Nuchido TIME+ clinical trial for was a randomized, double-blinded, placebo-controlled crossover trial.  

• This trial design is considered one of the gold standards in clinical research.  
• By employing a randomized and double-blinded approach, the trial minimized bias and ensured that the results were as objective as possible. 

Were the results of the trial comparable to other trials in the field of NAD supplementation? 

• It's important to place the trial results in the context of existing research.  

• Limited human trials on NAD supplementation, such as NMN and NR, make Nuchido TIME+'s comprehensive clinical trial all the more remarkable.  
• The scarcity of such trials in this specific area underscores the pioneering nature of Nuchido's research and sets them apart from their competitors. 

Was the trial conducted by reputable scientists and researchers in the field? 

• To ascertain the credibility of the trial, it's essential to evaluate the credentials of the scientists involved.  

• Nuchido Lead Scientist Dr. Nichola Conlon, has had extensive experience with designing and conducting such trials.  
• This brings expertise and credibility to the research.  
• Considering the reputation and qualifications of the scientists involved helps establish the standard of the trial. 

Did the trial assess multiple outcomes related to NAD+ and aging? 

• The trial not only focused on NAD+ levels but also examined other key markers of aging. 
• These included the NAMPT enzyme, SIRT1 levels, inflammation, and glycated serum protein.  
• This multi-faceted approach demonstrates the trial's comprehensive nature and provides a more holistic evaluation of Nuchido TIME+'s efficacy.  

Now that we've thoroughly established the clinical trial's credibility, validity, and gold standard ranking, Let's have a look at the results. 

The key findings of the Nuchido TIME+ dietary supplement trial are:

TIME+ IS SUPPORTED BY CLINICAL RESEARCH 

A randomised, double-blinded, placebo-controlled crossover clinical trial was performed on the Nuchido TIME+ dietary supplement.  

Participants were male and female, aged 20-80 years old.  

TIME+ BOOSTS CELLULAR NAD+ LEVELS 

Our patented formulation significantly increased      

NAD+ after 28 days of supplementation. 

TIME+ was found to significantly increase NAD+  levels after only 7 days of supplementation. 

  

TIME+ restored the body’s own natural NAD+ producing Salvage Pathway 

Declining levels of the NAD+ recycling enzyme NAMPT is the leading cause of age-related NAD+ decline  

TIME+ was found to increase levels of the NAMPT enzyme after 28 days of supplementation.

  

TIME+ increased the longevity protein SIRT1 

SIRT1 is a NAD+-dependent enzyme that coordinates many of the health-promoting effects of NAD+  

TIME+ was found to significantly increase SIRT1 after 28 days of supplementation.  

  

TIME+ reduced biological age 

Your biological age is how old you are on the inside. 

TIME+ was found to reduce biological age by an average of 1.26 years after 28 days of supplementation.  

The GlycanAge biological age test is available as a consumer kit allowing customers to test the efficacy of TIME+. 

 

TIME+ reduced inflammation 

Inflammation is a leading cause of cellular aging 

TIME+ was found to reduce inflammatory factors (cytokines IL-2, IL-5 and IL-23) after 28 days of supplementation. 

 

TIME+ reduced glycation 

Glycated serum proteins are precursors to advanced glycation end-products (AGES) which are highly correlated with aging and multiple age-related issues.  

TIME+ was found to decrease glycated serum protein after 28 days of supplementation.

  

TIME+ did not have any significant effect on biomarkers of safety. 

Standard liver function biomarkers were measured to ensure product safety. 

There were no significant differences between placebo and TIME+ indicating no toxic effect on liver function and the supplement is safe and well tolerated.

 

 SUMMARY of CLINICAL TRIAL RESULTS.

A randomised, double-blind, placebo-controlled crossover study of TIME+  

Demonstrated 

• Nuchido TIME+ significantly increases cellular NAD+ after only 7 days 

• Unlike NR or NMN it works by switching back on youthful cellular NAD+ production by reactivating a key enzyme in the Salvage Pathway (NAMPT) 
• An increase in the longevity protein SIRT1, a downstream target of NAD+ 
• A reduction of inflammatory cytokines indicating that NAD+ is being directed towards beneficial processes rather than inflammatory CD38 
• A reduction in biomarkers of glycation 
• A reversal of biological age  

Nuchido’s TIME+ is not just any ordinary dietary supplement. Its effectiveness has been put to the test through a clinical trial, making it a standout in the industry.  

Nuchido TIME+ is a game-changer in the fight against aging. 

Don't settle for subpar solutions or untested claims. Choose Nuchido TIME+ and experience the incredible results for yourself.  

It's time to take control of your aging process and rewrite your story, one youthful day at a time.  

References 

[1] Nichola Conlon, Dianne Ford,  Biochemical Pharmacology Volume 198, April 2022, 114946. “A systems-approach to NAD+ restoration”