Longevity genes are a group of genes that have been found to play a role in extending lifespan and promoting healthy ageing . 1
These genes are involved in various cellular processes, including DNA repair, cellular metabolism, and stress response.
One well-known group of longevity genes is the “Sirtuin” family, which includes genes such as SIRT1, SIRT3, and SIRT6.
Sirtuins are a class of proteins that require the coenzyme NAD+ (Nicotinamide Adenine Dinucleotide) to function properly.
They are involved in regulating gene expression, cellular metabolism, and stress response pathways . 2
Supporting longevity genes can be achieved through various lifestyle factors and interventions. Here are a few ways to support them:
- Exercise regularly: Exercise has been shown to increase the expression of sirtuins and other longevity genes . 3
- Eat a healthy diet: A diet rich in fruits, vegetables, whole grains, and lean protein can help support longevity genes . 4 5
- Reduce stress: Chronic stress can lead to inflammation and damage to cells. Practices such as meditation and yoga can help reduce stress levels . 6
- Get enough sleep: Sleep is essential for cellular repair and regeneration. Aim for 7-9 hours of sleep per night.
In addition to these lifestyle factors, there are also supplements that can support longevity genes. One such supplement required for sirtuin function is an NAD+ precursor.
But you have to be careful which NAD+ precursor you use. Precursor-only supplements like NMN and NR have been used for a long time to boost NAD+ levels.
Recent research suggests that these precursors-only NAD supplements (like NMN and NR) may not be the best approach to restoring NAD+ levels.
This is because they do not address the underlying root cause of NAD+ decline and can potentially cause further cellular dysfunction, other health issues and a failure to repair the salvage pathway. 7
A more comprehensive option would be TIME+ NAD. This differs from traditional precursors-only NAD supplements because it offers a whole-system approach to the NAD issue by addressing the root cause of NAD+ decline.
By increasing NAD+ levels through Time+ NAD supplementation you can help support sirtuin activity.
It’s important to note that while supporting longevity genes can have benefits for healthy ageing, genetics only play a small role in overall lifespan.
Lifestyle factors such as diet, exercise, and stress management are still the most important factors for promoting healthy ageing.
In conclusion, supporting longevity genes through lifestyle factors such as exercise, diet, stress management, and sleep can have benefits for healthy ageing.
Supplements such as Time+ NAD can also support sirtuin activity by increasing NAD+ levels.
However, it’s important to remember that genetics only play a small role in overall lifespan.
References:
Inner Light In. (2015). List of Longevity Genes – A Must Read for Longevity. 1
Guarente L. (2013). Sirtuins in ageing and disease. Cold Spring Harbor symposia on quantitative biology, 78: 81-90. 2
Katya Vargas-Ortiz (2019) Exercise and Sirtuins: A Way to Mitochondrial Health in Skeletal Muscle Jun; 20(11): 2717. 3
Sinclair DA. (2005). Toward a unified theory of caloric restriction and longevity regulation. Mechanisms of ageing and development, 126(9): 987-1002. 4
Fontana L., Partridge L., & Longo VD. (2010). Extending healthy life span—from yeast to humans. Science (New York, N.Y.), 328(5976): 321-326. 5
Epel ES., McEwen B., Seeman T., Matthews K., Castellazzo G., Brownell KD., Bell J., Ickovics JR., & Adler NE. (2000). Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosomatic medicine, 62(5): 623-632 6
Dr. Axe. (n.d.). NAD Supplement Benefits, Uses, Dosage and Side Effects. Retrieved June 18, 2023 7