Discover why NAD+ is essential for your health and longevity. Explore the crucial role of NAD+ in cellular function and how NAD+ supplements, such as Nuchido TIME+, can increase your vitality as you age. 

Ageing gracefully—it's what we all strive for. But as the years roll on, our bodies face increasing battles against declining energy levels and cellular health.  

Wouldn't it be great if there was a secret ingredient that could help us maintain our vitality? Well, folks, there just might be — it's called NAD+. 

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every cell of our bodies and plays an essential role in countless cellular reactions and processes. [1] 

Think of it as a vital spark plug for your cells; without it, your car, aka body, can't get started.  

Sounds pretty important, right?  

Get the notebook out, as we dive into the top five reasons your body needs more NAD+ and how you can boost it with supplements like TIME+ NAD.  

NAD+: The Lifesaver You've Never Heard Of  

Without NAD+, You Just Wouldn't Exist!

Imagine running a marathon without any energy—no breakfast, no water breaks and no cheer squads pushing you forward. It sounds impossible, doesn't it?  

Well, that's what it's like for your cells when they don't have enough NAD+. The NAD+ fuels the mitochondrial reactions that convert food into the energy your cells need to function.    

So, if all your NAD+ suddenly disappeared, you'd be as good as gone in about half a minute. That means you would be dead in 30 seconds.  

Talk about a race against time! 

NAD+ Activates Your "Longevity Genes"

There's a family of seven proteins known as "sirtuins" and they are present inside every cell of your body. These little superstars are often called the "guardians of the genome" or the “longevity genes”.  

They play a crucial role in maintaining cellular health and switching off genes associated with ageing and a deteriorating state of health. [2]   

But here's the catch: your sirtuins are incapable of carrying out their very important duties in the absence of NAD+. 

So, when NAD+ levels decline with age, sirtuins struggle to function, which contributes to the aging process. [3] 

Low NAD+ Levels Herald Ageing

You're probably thinking, "If NAD+ is so important, why does its supply diminish as we age?" Good question.  

As we age, cellular levels of NAD+ decline by about 50% every 20 years. [4] Regrettably, this pattern persists. When you reach 40, your NAD+ levels are merely a quarter of their original amount, and this further diminishes to just 12.5% by the time you reach 60. 

Cells lose their youthful ability they had when we were younger to produce and recycle NAD+, and as we get older the demand for NAD+ within our cells increases. 

As a result of this drop in NAD+ levels, your cells have less energy and are less able to activate the genes (sirtuins) responsible for your longevity. [5] 

But don't lose hope! We'll discuss how to boost NAD+ levels soon. 

NAD+ Maintains DNA Health

Daily life is a battlefield for our DNA, with constant attacks from Ultraviolet (UV) light, pollution, poor diet and even our metabolism. [6]. Your cells are subjected to between 8,000 and 11,000 forms of DNA damage every day. [7] 

Thankfully, NAD+ is like a protective knight that activates DNA repair enzymes (PARPs) within our cells. [6] 

However, the decline in NAD+ levels with age means that cells struggle to maintain DNA health, leading to the accumulation of DNA damage and signs of ageing.  [8]

NAD+ Regulates Your Body Clock

Think of NAD+ as the conductor of your body's circadian rhythm (that's your internal 24-hour body clock).  

This rhythm not only dictates your sleeping patterns but also your energy levels, hormones, metabolism and NAD+ production.  

However, when NAD+ levels decline, you will notice a steady degradation in your sleep quality, which is an unavoidable aspect of the ageing process. 

This is concerning because researchers have found a link between irregular sleep cycles and metabolic problems like obesity, insulin resistance, heart disease, a weak immune system, inflammation and cancer. [9]

But it's not just about the physical changes. Poor sleep can also increase the risk of mental health issues such as depression, anxiety, and irritability, ultimately leading to a negative impact on an individual's personal relationships and productivity. [10]  

Studies show that maintaining NAD+ levels with age can help maintain a robust circadian rhythm. [11] 

There you have it—5 convincing reasons your cells want more NAD+.  

Studies have shown that increasing your NAD+ levels can reap multiple benefits, including those mentioned above. [12] 

NAD+ supplements, such as TIME+ NAD, do precisely this, restoring your cells' youthful ability to produce NAD+.  

So why not give it a shot?  

After all, living our best lives means getting the most out of our health, right?  

Here's to a brighter, healthier tomorrow, my friends! 

References

[1]  : Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism.

[2] Verdin, E. (2015). NAD⁺ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208–1213.

[3]  Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464–471.

[4]  Massudi, H., (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.

[5] : Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464–471. https://doi.org/10.1016/j.tcb.2014.04.002

[6] : Bürkle, A., Beneke, S., & Muiras, M. L. (2004). Poly(ADP-Ribosyl)ation, PARP, and Aging.

[7] : Matt Yousefzadeh  (2021) DNA damage—how and why we age?

[8] : Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899–916. https://doi.org/10.1016/j.molmed.2017.08.001

[9] : Goran Medic, (2017) Short- and long-term health consequences of sleep disruption

[10] :  Cara C Tomaso, (2020). The effect of sleep deprivation and restriction on mood, emotion, and emotion regulation: three meta-analyses in one

[11] : Peek, C. B., Affinati, (2013). Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice. Science

[12] : Mills, K. F., Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metabolism,